Karasawa Shirou was a former employee of NEFT and the founder and first director of F.L.A.G., until he became a Kanshu and was most likely "Kanshu #20". Karasawa Shirou is also the master of the Coffin Princess Ende and only founded F.L.A.G. to find Ende. After he found her, he faked his own death but his body was seriously damaged, only left his upper half of his body. Karasawa Shirou was also called "The Source of the Infection" and was responsible, for what happened on Hatsumi Island, too. In the end, he was literally defeated by Takao Ryuusei and was killed by Tougo Kazama.